Shows
Science SavvyI need RELIEF!!! Pain and the brain part 2Part two of this Science Savvy pain series explains how common painkillers work, why many provide limited relief, and how pain is shaped by nerves, the spinal cord, the brain, and emotion!! (emotion?!?!)... we even talk about porn, sexual arousal, and its impact on pain... the ffff
The episode covers common drugs like ibuprofen, paracetamol, local anesthetics (at your dentist office) through to not-so-common drugs like opioids. We also talk about why expectations, social support, and non-drug approaches matter - a little bit of hope man, please.
As always, the full bibliography below:
1. None...
2026-02-1735 minScience SavvyIt HURTS! Pain and the Brain part 1Pain is weird. You only feel it in your brain… yet your brain has no pain receptors.
In part 1 of this 3-episode series, we unpack why pain is less a “signal” and more a decision your nervous system makes to feel it, shaped by reflexes, memory, mood, and context. You will learn why a hot stove makes you yank your foot back before you even feel anything, how “sharp” and “throbbing” travel on different nerve highways, and why chronic pain can become a disease of its own.
We discuss mind-bending paradoxes like phantom limb pain, referred pain...
2026-01-2621 minScience SavvySiestas & Sleepless Nights: The Science of Sleep - Part 2This episode dives into cultural sleep patterns, the science-backed benefits and timing of naps, and how circadian rhythms and so-called "sleep pressure" affect night time sleep.
It also covers sex and age differences in sleep needs, the risks of too little or too much sleep, and practical sleep hygiene tips to improve sleep quality.
Bibliography:
Blume C, Garbazza C, Spitschan M. Effects of light on human circadian rhythms, sleep and mood. Somnologie (Berl). 2019 Sep;23(3):147-156. doi: 10.1007/s11818-019-00215-x. Epub 2019 Aug 20. PMID: 31534436; PMCID: PMC6751071.
Chen, Chun-Lin et al. “Associations among sl...
2025-12-2626 minScience SavvySleeping Tight and Why It Matters: The Science of Sleep - Part 1This episode explores why sleep is SUPER important for body repair, immune function, literally cleaning your brain, and protecting you from diseases like Alzheimer's.
We get into some FUN topics like dreams: why we dream, whether there are any benefits to dreaming, and how sleep is different for different animals.
Give it a listen, and stay tuned for part two!
Bibliography:
Blume C, Garbazza C, Spitschan M. Effects of light on human circadian rhythms, sleep and mood. Somnologie (Berl). 2019 Sep;23(3):147-156. doi: 10.1007/s11818-019-00215-x. Epub 2019 Aug 20. PMID: 31534436; PMCID: PMC6751071.
2025-12-1631 minScience SavvyGoing on a Trip: Science of PsychedelicsIn this episode, I explore the history, science, and clinical promise of psychedelics. This was actually my Master's Thesis topic so very fun episode for me!
We cover everything from how the psychedelics actually work, by acting brain (serotonin) receptors to increase neuroplasticity (make your brain more malleable), disrupt rigid brain patterns, and increase brain "entropy"... and, more importantly, why those effects may help us treat conditions such as PTSD and treatment‑resistant depression.
The episode also discusses the current clinical evidence (including a critical appraisal of its robustness), logisitcal and ethical challenges, and the im...
2025-11-0736 minScience SavvyYou will Never Forget this Episode: Science of MemoryIn this episode of Science Savvy, I explore how memory shapes identity and human culture.
The episode covers the evolutionary origins of memory, the brain regions involved, how memories are encoded, and how therapies (including MDMA) can help heal traumatic memories.
You will also get practical tips to improve your memory!
About Science Savvy: My name is Carmen Fairley, I have a background in pharmacology and biomedical engineering, and currently work in medical advisory. Science Savvy is a podcast that makes cutting-edge research accessible, turning complex science into stories that mean something for...
2025-10-1728 minScience SavvyCris Cancer: Who is funding tomorrow's cancer cure?In this episode of Science Savvy, I sit down with Elena Muyo, Scientific Projects & Partnerships Lead at CRIS Cancer UK, to uncover how this unique charity is rewriting the future of cancer research. From dual CAR-T trials in children with leukemia, to a first-in-class lung cancer vaccine, to pioneering treatments for devastating childhood brain tumors, CRIS Cancer is driving science that gives patients options when medicine says “there’s nothing more we can do.”
We talk about the incredible story that started it all, how CRIS selects and funds projects that others overlook, and why every pound donate...
2025-09-2640 minScience SavvyGenetics of Schizophrenia with Aitana PadillaIn this episode we talk about "having great genes", but also weird ones, ancient viral ones, and even one named after Sonic Hedgehog (look it up!). W dive into how your DNA is more like a script with a dimmer switch than a fixed destiny. From epigenetics and retroviruses to schizophrenia research, stem cells, and the pitfalls of 23andMe, we explore the science written into your genome.
Thank you to Aitana Padilla for coming on the show. Aitana is a neuroscientist in training with a deep focus on the genetics of mental health. She currently investigates how...
2025-09-0429 minScience SavvyGenetics: You Are More Viral Than You ThinkWelcome to the Genetics episode, part of Science Savvy with Carmen. In this episode, I am joined by neuroscientist and PhD researcher Aitana Padilla Requerey. Leveraging my background in pharmacology and biomedical engineering, I speak with Aitana to better understand gene expression, viral DNA, and genetic editing.
This episode covers the role of ancient viral elements embedded in our genome, how epigenetics acts like a dimmer switch on gene activity, and how genetic tools like CRISPR are changing the future of medicine. Aitana earned her Bachelor of Science in Neuroscience from UCLA, graduating with a perfect 4.0 GPA...
2025-07-0837 minScience SavvyBuilt to Be Mid: The Evolutionary Problem With HappinessWelcome to this Science Savvy episode on Happiness. In this episode, I explore what happiness really is from a neuroscience & evolutionary perspective, and explain why it’s a biological miracle that we feel joy at all.
I have a background in pharmacology and biomedical engineering, and in this episode I cover why dopamine gets all the hype (but shouldn’t), how gratitude rewires your brain, why you’re not supposed to be happy all the time, and what Tibetan monks can teach us about brain waves and contentment.
Science Savvy helps you understand the systems shapin...
2025-06-0335 minScience SavvyBoss?! How our brains make (and break) trust with Dr. D'AmicoIn this episode, I am joined by Dr. Katharine D'Amico, a behavioral neuroscientist and President of the The Swala Institute for Applied Neuroscience for professional communication. We explore how your brain rapidly forms perceptions, builds (or breaks) trust, and makes high-stakes decisions.
My name is Carmen, I am the host of Science Savvy. I have a background in pharmacology and biomedical engineering. Science Savvy podcast is all about breaking down the extraordinary science behind everyday life.
In this episode, Dr. D'Amico shares her insights from mentoring over 900 startups and researching how trust and emotion shape...
2025-05-1538 minScience SavvyBuilding (and breaking) Trust: Neuroscience of decision-making with Dr. Katharine D’AmicoIn this episode, I am joined by Dr. Katharine D'Amico, a behavioral neuroscientist and President of the The Swala Institute for Applied Neuroscience for professional communication. We explore how your brain rapidly forms perceptions, builds (or breaks) trust, and makes high-stakes decisions, often without you even realizing it. With my background in pharmacology and biomedical engineering, I talk to Dr. D'Amico about break down the science behind decision-making, emotional bias, and neurochemistry, and unpack how these processes show up in leadership, relationships, and daily life.
Dr. D'Amico shares her insights from mentoring over 900 startups and researching how...
2025-05-1340 minScience SavvyBuilding Minds: How Architecture Shapes Our Lives and Well-BeingWelcome to the Architecture and the Brain episode, part of Science Savvy with Carmen. In this episode, I explore how the built environment influences the way we think, feel, and connect with others. With my background in pharmacology and biomedical engineering, I break down the science behind sensory perception and neuroarchitecture, and unpack how it shows up in your daily life.
This episode covers the psychology of shared spaces, the impact of natural light and materials on mood and cognition, and why we’re hardwired to respond to beauty. I’m joined by Antonio, a talented architect, as w...
2025-04-2234 minScience SavvyPCOS: The Reality Show Where No Egg Wins with Dr. FarisWelcome to the PCOS episode, part of Science Savvy with Carmen. In this episode, I explore the science behind Polycystic Ovarian Syndrome, a complex hormonal and metabolic condition that affects millions of women worldwide. With my background in pharmacology and biomedical engineering, I break down the mechanisms behind PCOS and unpack how it shows up in your daily life.
This episode features a conversation with Dr. Basma Faris, a board-certified OB/GYN and certified culinary medicine specialist. We discuss why PCOS is not just about cystic ovaries, how insulin resistance contributes to hormonal imbalance, and the ways...
2025-04-0142 minScience SavvyFood for Thought: How What You Eat Shapes Your Mind, Body, and RelationshipsWelcome to the Food and the Brain episode, part of Science Savvy with Carmen. In this episode, I explore how the food we eat shapes not only our physical health but also our brain, behavior, and social bonds. With my background in pharmacology and biomedical engineering, I break down the science behind nutrition and neurobiology and unpack how it shows up in your daily life.
This episode covers how taste, smell, and texture stimulate the brain’s reward system, the role of the gut-brain axis in mood and cognition, and how specific nutrients like omega-3s can su...
2025-03-1126 minScience SavvyMind over Migraine: Former MP Dehenna Davison on Battling the Invisible PainWelcome to the Migraine episode, part of Science Savvy with Carmen. In this episode, I explore the science, stigma, and impact of migraine through the lens of lived experience and neuroscience. With my background in pharmacology and biomedical engineering, I break down the biology behind migraine and unpack how it shows up in your daily life.
This episode features a conversation with Dehenna Davison, former Member of Parliament for Bishop Auckland, who made headlines when she stepped down from her dream job due to chronic migraine. Dehenna shares her journey from suffering in silence to securing the...
2025-02-1842 minScience SavvyLasting habits I think you should build or Neuroplasticity 101Welcome to the Neuroplasticity episode, part of Science Savvy with Carmen. In this episode, I explore the incredible adaptability of the brain and what it means for learning, healing, and growth. With my background in pharmacology and biomedical engineering, I break down the science behind neuroplasticity and unpack how it shows up in your daily life.
This episode covers the story of JJ, a boy who was born missing key brain structures but still outperformed his peers academically. We use his story to explore how the brain can rewire itself under extraordinary conditions and what that means...
2025-01-2833 minScience SavvyMake 2025 your b!tch: Brain hacks to build lasting habitsWelcome to the New Year Habits episode, part of Science Savvy with Carmen. In this episode, I explore how to build better routines using neuroscience-backed strategies. With my background in pharmacology and biomedical engineering, I break down the science behind focus, motivation, and habit formation, and unpack how it shows up in your daily life.
This episode covers how dopamine drives reinforcement, how your prefrontal cortex shapes goal setting, and how small actions can rewire your brain over time. I share five practical, research-based strategies to help you start small, reward progress, build flexibility, embrace accountability, and...
2025-01-0729 minScience SavvyAll you need is LOVEWelcome to the Love episode, part of Science Savvy with Carmen. In this episode, I explore the biology behind one of humanity’s most powerful emotions. With my background in pharmacology and biomedical engineering, I break down the science behind love and unpack how it shows up in your daily life.
This episode covers the three stages of love known as lust, attraction, and attachment. Together with my friend Alejandra, we explore how hormones like oxytocin, vasopressin, dopamine, and cortisol shape our connections and influence everything from butterflies to heartbreak. We also look at the brain’s resp...
2025-01-0431 minScience SavvyThe Science of Friendship: Giggles, Bonding, and LearningIn this episode of Science Savvy, I’m joined by my best friend of ten years, Dasha, to explore the science behind long-term friendship. With warmth, laughter, and a healthy dose of evidence-based insight, we look at how your brain syncs up with your closest companions, why oxytocin makes you feel safe and connected, and how staying close to your friends can actually support your physical health and longevity.
We discuss how friendship shapes the brain, buffers stress, and even extends lifespan. Whether you're curious about how social bonds work or simply love your bestie and want to...
2025-01-0427 minScience SavvyAttention, Please: What ADHD Can Teach Us About the BrainWelcome to the ADHD episode, part of Science Savvy with Carmen. In this episode, I explore what it really means to live with ADHD and how science is reshaping the way we understand it. With my background in pharmacology and biomedical engineering, I break down the science behind attention, dopamine, and neurodiversity, and unpack how it all shows up in everyday life.
This episode covers how neurotransmitters like dopamine and norepinephrine influence focus, what makes ADHD more of a difference than a deficit, and how modern life and social media interact with attention challenges. I’m joined by...
2024-12-2438 minScience SavvyWired for Wonder: Neuroscience of CreativityWelcome to the Creativity episode, part of Science Savvy with Carmen. In this episode, I explore the science behind creative thinking and how the brain fuels imagination. With my background in pharmacology and biomedical engineering, I break down the science behind creativity and unpack how it shows up in your daily life.
This episode covers the roles of the prefrontal cortex and default mode network, the surprising impact of dopamine on creative flow, and how certain brain states enhance idea generation. Joined by my friend Alicia, an artist and entrepreneur with a background in psychology, we look...
2024-12-1030 minScience SavvyYou Are What You Eat: The Gut Microbiome Shapes Mood, Health, and BehaviorWelcome to the Gut Health episode, part of Science Savvy with Carmen. In this episode, I explore how your gut microbiome does so much more than support digestion. With my background in pharmacology and biomedical engineering, I break down the science behind the gut-brain connection and unpack how it shows up in your daily life.
This episode covers how gut bacteria influence your mood, mental health, immune function, and even decision-making. I share fascinating research on the relationship between the microbiome and depression, explain the biological pathways linking your gut to your brain, and offer practical tips...
2024-11-2633 minScience SavvyWho the F*!k am I? Science of Consciousness & Self-AwarenessWelcome to the Consciousness episode, part of Science Savvy with Carmen. In this episode, I explore what it really means to be conscious and how self-awareness shapes who we are. With my background in pharmacology and biomedical engineering, I break down the science behind consciousness and unpack how it shows up in your daily life.
This episode covers everything from classic philosophical ideas like Descartes’ “I think, therefore I am” to modern neuroscience frameworks such as Crick’s Astonishing Hypothesis and Tononi’s information integration theory. We explore how brain chemistry, genetics, and personal experience come together to influen...
2024-11-1226 minScience Savvy[Interview tester] All you need is LOVEThis is one of our early interview episodes. We shared a microphone and the audio is a bit raw, so feel free to check out our latest episodes for a more polished experience.
Welcome to the Love episode, part of Science Savvy with Carmen. In this episode, I explore the biology behind one of humanity’s most powerful emotions. With my background in pharmacology and biomedical engineering, I break down the science behind love and unpack how it shows up in your daily life.
This episode covers the three stages of love known as lust, at...
2024-10-2932 minScience SavvyPeriods - Why Can’t Mother Nature Just Text Me I'm Not Pregnant?In this episode of Science Savvy, we tackle one of the most common yet least understood experiences in women’s health: why do we get periods. From evolutionary theories to hormonal rollercoasters, I explore the biology and history behind menstruation and the science that underlies symptoms like bloating, mood swings, and acne. With my background in pharmacology and biomedical engineering, I break down why periods exist in the first place and what they can reveal about your health.
We look at the theories around menstruation as a defense mechanism, the evolution of concealed ovulation, and how different ph...
2024-10-1519 minScience Savvy[Interview tester] The Science of Friendship: Giggles, Bonding, and LearningThis is one of our early interview episodes. We shared a microphone and I hadn't yet perfected my audio editing, so feel free to check out our latest episodes for a more polished experience.
In this episode of Science Savvy, I’m joined by my best friend of ten years, Dasha, to explore the science behind long-term friendship. With warmth, laughter, and a healthy dose of evidence-based insight, we look at how your brain syncs up with your closest companions, why oxytocin makes you feel safe and connected, and how staying close to your friends can actually su...
2024-10-0821 min
Science Savvy[Pilot] How Our Brains Predict and Shape Everyday LifeThis is one of our early episodes. We shared a mic and the audio is a bit raw, so feel free to check out our latest episodes for a more polished experience.
Welcome to the first episode of Science Savvy with Carmen. In this episode, I explore how our brains work as prediction machines to help us make sense of the world around us. With my background in pharmacology and biomedical engineering, I break down the science behind how the brain constantly anticipates and adapts to everyday experiences.
This episode dives into how your brain...
2024-10-0524 min