Shows
Thrombosis in conversationEpisode 31: Optimising treatment duration for thrombosis“Just being upfront with patients about those areas of uncertainty can be really helpful…” Dr Deborah Siegal and Dr Barnes break down best practices for balancing safety and efficacy when deciding how long to continue anticoagulation therapy for thrombosis. They discuss ways to reassure patients during an uncertain time, highlight key factors that modify bleeding risk, and explain how ongoing follow-up and reassessment are important in driving better outcomes.
2025-10-1025 min
Unlocking Myasthenia gravisEpisode 17 – The urgency of myasthenic crisisEpisode 17 - Tobias Ruck joins Nils Erik Gilhus to share his experience managing a compelling case involving a patient with recurrent crises and respiratory failure. Together, they discuss how to identify early red flags and emphasize the importance of timely intervention before respiratory compromise becomes critical.
2025-10-0822 minThrombosis in conversationEpisode 30: VTE and AF at ESC 2025“I think this was such an important trial, certainly one that has changed my practice already.” Dr Barnes welcomes Dr Marco Proietti for a review and discussion of key studies presented at ESC 2025, including AMALFI, ALONE-AF, and HI-PRO. Which results were practice-changing, which were reassuring, and which are of uncertain value or highlight a need for new therapeutics?
2025-09-1036 minUnlocking Myasthenia gravisEpisode 16 - Life beyond MGEpisode 16 – Professor Nils Erik Gilhus welcomes Professor Francesco Saccà to discuss quality of life in people with MG, including the outsized impact of unpredictable symptoms, striking the right balance when informing patients about the risk of myasthenic crisis, and how encouraging patients to regularly self-report symptoms can influence both wellbeing and treatment planning.
2025-03-2016 minUnlocking Myasthenia gravisEpisode 15 - The nature of myasthenia gravisEpisode 15 – Professor Francesco Saccà joins Professor Nils Erik Gilhus to delve into the pathophysiology of MG, discussing the role of the complement system, what determines whether MG is a fully reversible disease, and the necessity of accurate biomarkers for personalised care. They also discuss the different contributions of T and B cells to MG and how these may impact the success of targeted treatments.
2025-03-2015 minThrombosis in conversationEpisode 29: Individualised care in special populations“We must be patient centred.” Dr Steven Deitelzweig and Dr Barnes address the challenge of balancing bleed risk and thrombosis prevention in special populations, such as those with obesity, frailty, or chronic kidney disease. With up to 50% of patients not resuming anticoagulation following a bleed, they emphasise the importance of shared decision-making to guide treatment in patients for whom the evidence is uncertain.
2025-03-1819 minThrombosis in conversationEpisode 28: Real-world evidence: Addressing gaps in VTE and AF clinical researchWhat makes good real-world evidence (RWE), and why does it matter? Dr Steven Deitelzweig joins Dr Barnes to discuss how physicians can assess the quality of RWE and its potential to expand our understanding of the safety and effectiveness of treatments beyond clinical trial data, helping to guide anticoagulation in understudied populations.
2025-03-0620 minThrombosis in conversationEpisode 27: A multidisciplinary approach to CAT“As soon as you have a cancer diagnosis, the odds [of VTE] increase 4-fold, 6.5-fold if that particular patient is initiating chemotherapy.” Dr Marc Carrier and Dr Geoffrey Barnes use a case study to talk through the decision-making process and specific needs for anticoagulation in patients with cancer. They highlight the need for a multidisciplinary approach, how tools such as the Khorana score inform treatment, and the patient group that rarely receives thromboprophylaxis despite having a number needed to treat of just 25 to prevent one clot.
2025-02-1815 minThrombosis in conversationEpisode 26: From pragmatic trials to everyday treatment – DOACs for CATAround 50% of patients eligible for anticoagulation treatment do not meet the usual inclusion criteria for randomised controlled trials (RCTs). Dr Marc Carrier joins Dr Barnes for a discussion of three recent RCTs with a pragmatic approach – CANVAS, RENOVE, and ONCO PE – and how these have addressed important questions about the clinical approach to CAT, including how long to continue direct oral anticoagulation (DOAC) treatment and whether to reduce the dose.
2025-02-0419 minThrombosis in conversationEpisode 25: AF and CKD – A “tight association”“We have to be careful about who we label with chronic kidney disease.” Dr Piazza returns to talk to Dr Barnes about renal dysfunction in the context of AF, including the factors to consider to ensure a clinically relevant diagnosis, why intentional underdosing of anticoagulants may do more harm than good, and the use of warfarin versus direct oral anticoagulants in patients with end-stage renal disease.
2025-01-2123 min
All Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 101 - Live from Global Urticaria ForumEpisode 101 – What were the highlights at Global Urticaria Forum (GUF) 2024? Professor Torsten Zuberbier and Dr Sophia Neisinger share their live reflections on the 7th Global Allergy and Asthma Excellence Network GUF event, including personal highlights, tips for junior physicians to make meaningful contributions to meetings and details on GUF 2025.
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2025-01-0710 minThrombosis in conversationEpisode 24: Clinical considerations: Managing treatment switchesClinical pharmacist Dr Arthur Allen joins Dr Barnes to discuss how to navigate transitions between anticoagulants, including when and why to use bridging low-molecular-weight heparin, the patient characteristics that may influence management, and why switching guidance in the prescribing information is not practical. Also, amid local variations in care models and cultures, what is the key factor that can determine the success of physician–pharmacist collaborative care?
2025-01-0720 minThrombosis in conversationEpisode 23: From hospital to community: Transitions in VTE careDr Piazza and Dr Barnes discuss how collaboration and a clear message can ease the transition from hospital to home, and the return to daily routines, for people recovering from VTE. Our experts discuss the optimal timing of thrombophilia testing, supporting medication adherence and getting patients moving again.
2024-12-1820 minThrombosis in conversationEpisode 22: Selecting anticoagulants: Individualised approaches“We can definitely utilise each other’s strengths and expertise and make some synergy. We all have the same goal here.” Clinical pharmacist Dr Sara Vazquez and Dr Barnes discuss how physicians and pharmacists can collaborate to create more effective, individualised treatment approaches, and outline strategies to ensure patients are meaningfully involved in decisions about their treatment.
2024-12-0314 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 100 - Urticaria Day 2024Episode 100 – In this special episode, recorded on Urticaria Day (UDAY), Professor Torsten Zuberbier and Dr Carolina Vera welcome CSU patient advocate Kristen Willard, who shares her story of living with urticaria. With live audience participation, this episode also delves into the cause of itch, the impact of urticaria on mental health, and novel treatments.
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2024-12-0230 minThrombosis in conversationEpisode 21: Optimising adherence in anticoagulation therapyDr Barnes and Dr Sara Vazquez consider the diverse factors that influence patients’ adherence to anticoagulant therapy, including “nuisance bleeding”, pill burden, and whether treatment is to prevent AF or VTE. They also look at different ways to build habits that can work for different individuals, and Dr Vazquez offers practical tips for effective communication with patients about their medications.
2024-11-2016 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 99 - How should I treat patients who experience a slow or partial response?Professors Torsten Zuberbier and Dave Khan share their experiences and approaches to treating people with refractory CSU, noting the importance of ensuring a correct diagnosis and following guideline recommendations.
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For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.
2024-11-1222 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 98 - Living with CSU: The patient outlook“It stops my daily life as I know it.” Patient advocate with CSU Kristen Willard joins Professor Torsten Zuberbier to reflect on navigating life with CSU, including the impact on quality of life, potential triggers and the uncertainty around the disease.
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For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website...
2024-11-0520 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 97 - Clinical trials in urticaria: Part 2This episode was recorded before 31 July 2024. Professor Marcus Maurer, Dr Carolina Vera Ayala, and Associate Professor Jonny Peter discuss how new therapeutics progress through the development pipeline, noting the “huge amount of data” required on safety before a molecule enters clinical trials. They also shed light on drug repurposing and why children are a “critical group” for inclusion in trials.
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Additional resources for this episode: Chronic urticaria: unmet needs, emerging drugs, and new perspectives on personalised treatment
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2024-10-1129 minUnlocking Myasthenia gravisEpisode 14 - New and improved assays for detecting antibodiesEpisode 14 – Cell-based diagnostic assays now available for MG are more sensitive than previous assays, but “are they as specific?” Professor Nils Erik Gilhus and Dr Gregorio Spagni discuss sensitivity and specificity of these new assays, as well as cost and ease of use.
2024-09-2316 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 96 - All things acute urticaria: Part 2[This episode was recorded before 31 July 2024.] "Every chronic urticaria starts as acute urticaria, but not every acute urticaria becomes chronic." Associate Professor Dr Andaç Salman and Professor Marcus Maurer discuss causes of acute urticaria, how diagnosis and management can be improved, and UCARE’s research into drivers of “chronification”.
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Additional resources for this episode: Acute and chronic urticaria diagnosis and management taking into account their differences; Acute urticaria – GA2LEN UCARE 2023 conference presentation and Project: CHAPEAU – GA2LEN UCARE Network
Acc...
2024-09-2029 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 95 - The similarities and differences between urticaria and mastocytosisThis episode was recorded before July 31, 2024. Professor Marcus Maurer and Dr Sigurd Broesby-Olsen discuss similarities and differences between urticaria and mastocytosis, two mast cell diseases. They then turn their attention to treatment, sharing their thoughts on ‘killing’ mast cells and the development of more targeted and less toxic therapies.
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Additional resources for this episode: Mast cell silencing: A novel therapeutic approach for urticaria and other mast cell-mediated diseases; Mast cell–targeting therapies in mast cell activation syndromes; and Tyrosine kinase...
2024-09-1220 minThrombosis in conversationEpisode 20: “If you measure it, you can improve it” – AI for managing AFArtificial intelligence (AI) in cardiovascular care is empowering researchers and clinicians to uncover new findings that were previously undetectable. These data enable more sophisticated conclusions for guiding clinical decision-making. Dr Rohan Khera joins Dr Barnes to examine the present and future impact of AI technologies on the management of AF.
2024-08-2216 minThrombosis in conversationEpisode 19: Does obesity positively impact direct oral anticoagulation outcomes?Dr Barnes and Dr Karlyn Martin discuss how recent data have informed opinions on the safety and efficacy of using direct oral anticoagulants (DOAC) in people with obesity and thrombosis. Dr Martin considers DOACs for people who have received bariatric surgery, and if guidelines for DOAC use in patients with comorbid obesity and VTE apply to other groups with thrombosis.
2024-08-2221 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 94 - The scientific approach to urticaria: Part 2"We will only be able to cure this disease and treat it well if we know how it works." Back by popular demand, Dr Jörg Scheffel rejoins Professor Marcus Maurer to discuss the importance and intricacies of mast cell research in urticaria.”
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Additional resources for this episode: A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells; and Isolation and Culture of Human Skin Mast Cells.
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2024-08-0625 minThrombosis in conversationEpisode 18: “Can’t I just use an aspirin instead?”Host Dr Geoffrey Barnes and Dr Sara Vazquez review treatment options for stroke prevention in patient groups with AF and discuss overcoming patient and physician barriers to initiating optimal treatment. Dr Barnes observes: “Patients will often bring interesting stories that influence their ability to make a decision.”
2024-07-2920 minUnlocking Myasthenia gravisEpisode 13 – EAN 2024 specialEpisode 13 – Professor Jan De Bleecker joins Professor Nils Erik Gilhus to reflect on EAN 2024 and discuss key congress highlights, including information on therapeutic advances in MG.
2024-07-2917 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 93 - The use of corticosteroids in urticariaDr Maryam Ali Al-Nesf joins Professor Marcus Maurer to discuss one of the big burdens of chronic urticaria: the "use, or should we say abuse, of cortisone" in chronic spontaneous urticaria.
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Additional resources for this episode: Efficacy and safety of systemic corticosteroids for urticaria: A systematic review and meta-analysis of randomized clinical trials; and A patient charter for chronic urticaria.
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2024-07-2321 minThrombosis in conversationEpisode 17: Anticoagulation for atrial fibrillation and comorbid obesityDr Geoffrey Barnes and Dr Gregory Piazza examine when ongoing weight-adjusted dosages are necessary in a patient with AF and obesity, best practices for monitoring renal function and medication levels, and specific lifestyle modifications.
2024-07-2220 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 92 - Obesity and urticariaProfessor Christian Vestergaard and Professor Marcus Maurer discuss the link between obesity and urticaria, including how obesity contributes to chronic inflammation and the importance of P4 medicine (preventive, predictive, personalised, participatory) in urticaria treatment.
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Additional resources for this episode: High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria; and Risk of comorbidities in patients diagnosed with chronic urticaria: A nationwide registry-study.
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2024-07-0927 minThrombosis in conversationEpisode 16: Stroke prevention in AF with high bleeding riskMitigating the risk of stroke in people with high bleeding risk can be a challenging balancing act. Dr Potpara and Dr Barnes discuss how these risks can be addressed, and how “patients should not be denied effective therapies because of concerns that can be managed in other ways”.
2024-07-0322 minThrombosis in conversationEpisode 15: Stroke prevention in older adults with AFDr Tatjana Potpara and Dr Barnes focus on managing stroke risk in older adults with AF, highlighting the clinical challenge of balancing bleeding risk with the benefits of anticoagulants.
2024-07-0325 minUnlocking Myasthenia gravisEpisode 12 – Late-onset myasthenia gravisProfessor Nils Erik Gilhus welcomes Professor Ernestina Santos to discuss late-onset MG, including the definition of late onset versus early onset, diagnostic and treatment challenges, and physical activity recommendations for these patients.
2024-06-2818 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 91 - EAACI 2024Professor Marcus Maurer and Professor Martin Metz reflect on the European Academy of Allergy and Clinical Immunology (EAACI) congress 2024, including novel treatments on the horizon, key takeaways and expectations for future meetings.
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Additional resources for this episode: Remibrutinib demonstrates favourable safety profile and sustained efficacy in chronic spontaneous urticaria over 52 weeks; andEuropean Medicines Agency approved indications for omalizumab biosimilar.
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2024-06-2527 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 90 - The scientific approach to urticariaProfessor Marcus Maurer welcomes Dr Jörg Scheffel to discuss urticaria, including techniques used to interrogate mast cells and examine interstitial fluid, and a technique used to identify autoimmune-mediated forms of urticaria.
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Additional resources for this episode: Chronic urticaria and the pathogenic role of mast cells;A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells; Autoreactive IgE: Pathogenic role and therapeutic target in autoimmune diseases.
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2024-06-1127 minThrombosis in conversationEpisode 14: Wearables: Are they ready for the prime time?Dr Jackson and Dr Barnes take a closer look at the hot topic of wearable devices in AF detection – their potential benefits and limitations – and how physicians can best discuss wearables with their patients.
2024-06-0619 minThrombosis in conversationEpisode 13: Patient case study: Older and frail adult with AF at high risk of bleedingDr Larry Jackson and Dr Barnes consider how best to tackle a patient case study with a focus on optimal management of AF in older patients at high risk of bleeding.
2024-06-0619 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 89 - Is clinical remission in urticaria possible?Professor Elias Toubi joins Professor Marcus Maurer to discuss remission in urticaria, including its definition and possible risk factors for long disease duration.
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Additional resources for this episode: Clinical and laboratory parameters in predicting chronic urticaria duration: A prospective study of 139 patients.
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For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACAR...
2024-05-2826 minUnlocking Myasthenia gravisEpisode 11 – Steroids in myasthenia gravisProfessor Tarek Sharshar joins Professor Nils Erik Gilhus to discuss the use of steroids in people with MG, including dose recommendations, and treatment in the intensive care setting.
2024-05-1716 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 88 - Urticaria and sportAssociate Professor Elena Borzova joins Professor Marcus Maurer to discuss exercise as a trigger for urticaria in some athletes, including the paradoxical protective effect of exercise in people with urticaria.
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Additional resources for this episode: Exercise-induced urticaria: A rare case report; and Physical activity and mental health among patients with atopic dermatitis or chronic spontaneous urticaria: A cross-sectional study.
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2024-05-1728 minThrombosis in conversationEpisode 12: Unravelling AF and comorbiditiesDr Barnes and Dr Frederik Verbrugge take a closer look at the management of stroke risk in people with AF and comorbid conditions.
2024-05-0223 minThrombosis in conversationEpisode 11: Real-world evidence: Anticoagulation strategies for CAT“There’s no doubt that pharmacological prophylaxis is under used.” Dr Carrier and Dr Barnes discuss the real-world evidence underpinning strategy for the management of CAT.
2024-05-0222 minThrombosis in conversationEpisode 10: Cancer heterogeneity and CATDr Marc Carrier and Dr Barnes discuss the challenges posed by cancer heterogeneity when managing CAT.
2024-05-0221 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 87 - Clinical trials in urticariaProfessor Marcus Maurer welcomes Dr Carolina Vera Ayala and Associate Professor Jonny Peter to discuss participation in clinical trials for urticaria, including patient concerns around placebo treatment.
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Additional resources for this episode: What is clinical research and why is it done?
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For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Websi...
2024-04-3022 minUnlocking Myasthenia gravisEpisode 10 – Unmet needs in myasthenia gravisProfessor Nils Erik Gilhus welcomes Dr Sarah Hoffmann to discuss the challenge of unmet treatment needs in MG, particularly for subgroups under-represented in clinical trials, including those who are older, pregnant, or seronegative.
2024-04-1915 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 86 - CU: A Hong Kong perspectiveProfessor Marcus Maurer welcomes Professor Philip Li to discuss the management of urticaria in Hong Kong, including access to effective treatments and socioeconomic and cultural factors.
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Additional resources for this episode: Hong Kong–Macau severe hives and angioedema referral pathway, Disparities in chronic spontaneous urticaria: Eligibility for drug reimbursement associated with clinical outcomes, Chronic spontaneous urticaria in Hong Kong: Clinical characteristics, real-world practice and implications for COVID-19 vaccination
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2024-04-1825 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 85 - How can we educate dermatologists on urticaria?Dr Jason Hawkes joins Professor Marcus Maurer to discuss dermatologists’ lack of urticaria knowledge, including tips on encouraging the US dermatology community to use resources such as the CRUSE app.
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Additional resources for this episode: Key messages: Urticaria guidelines; Urticaria: A comprehensive review and Hives: Diagnosis and treatment.
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For more information about the UCARE/ACARE network and its activities, please visit...
2024-04-0223 minUnlocking Myasthenia gravisEpisode 9 – Pregnancy and myasthenia gravisDr Christiane Schneider-Gold joins Professor Nils Erik Gilhus to discuss pregnancy in people with MG, including special precautions for delivery and the risk of transient neonatal MG.
2024-03-2716 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 84 - Does country make a difference?“This is a global problem that requires global solutions, but I think they do come from what we learn in our settings.” Professor Marcus Maurer welcomes Dr Clive Grattan to discuss the differences in the treatment and management of urticaria across the UK and Germany, including guideline recommendations and new treatments on the horizon.
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Utilise the following external links and access additional resources relating to the topics discussed in this episode: British Association of Dermatologists guidelines for the management of p...
2024-03-2027 minThrombosis in conversationEpisode 9: Unmet medical needs in AF managementDr Proietti and Professor Lip highlight unmet needs in AF management for stroke prevention and their prevalence among people with AF.
2024-03-1915 minThrombosis in conversationEpisode 8: Real-world evidence for managing AF in stroke preventionCan real-world evidence improve treatment selection and individualised care for AF in stroke prevention? Dr Proietti and Professor Lip discuss.
2024-03-1914 minThrombosis in conversationEpisode 7: AF screening and detection technologies in stroke prevention“Wearable technologies for stroke prevention are an exciting trend in the field” Dr Proietti and Professor Lip examine the benefits and disadvantages of wearable technologies for AF screening and detection in stroke prevention.
2024-03-1915 minUnlocking Myasthenia gravisEpisode 8 – Diagnostic delay in myasthenia gravisProfessor Benedikt Schoser joins Professor Nils Erik Gilhus to discuss the challenge of diagnostic delay in people with MG covering possible reasons for delays and recommended clinical tests.
2024-03-0718 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 83 - Chronic Angioedema Registry (CARE)“I think CARE will grow and grow.” Dr Thomas Buttgereit joins Professor Marcus Maurer to discuss the recently launched Chronic Angioedema Registry (CARE), including benefits for patients, current capabilities and how to get involved.
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Utilise the following external links and access additional resources relating to the topics discussed in this episode: Chronic Angioedema Registry.
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2024-03-0529 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 82 - Managing autoimmune CSU“There’s still so much we need to learn.” Dr João Marcelino joins Professor Marcus Maurer to discuss autoimmune chronic spontaneous urticaria, including indicative test results and hopes for the future.
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Utilise the following external links and access additional resources relating to the topics discussed in this episode: What basophil testing tells us about CSU patients – results of the CORSA study, Autologous serum skin test reactions in chronic spontaneous urticaria differ from heterologous cell reactions and Omalizumab in chronic s...
2024-02-2026 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 81 - UCARE Conference 2023“It’s really a catalyst to what the network does.” Professor Marcus Maurer asks Dr Luis Felipe Ensina to reflect on the UCARE Conference 2023, covering personal highlights and expectations for future meetings.
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Utilise the following external links and access additional resources relating to the topics discussed in this episode: UCARE Conference 2023.
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2024-02-0723 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 80 - Living with CSU: The patient’s voice“It doesn’t just affect one part of your life.” Arzoo Ahmed joins Professor Marcus Maurer to discuss the patient perspective, covering the reality and challenges of living with chronic spontaneous urticaria.
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Utilise the following external links and access additional resources relating to the topics discussed in this episode: Our Future Health.
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2024-01-2927 minUnlocking Myasthenia gravisEpisode 7 – Physical exercise in myasthenia gravis“It’s a matter of finding the right exercise type, based on the personality.” Professor Anna Rostedt Punga joins Professor Nils Erik Gilhus to discuss the benefits of physical therapy in people with myasthenia gravis, how to deal with more complex cases and the importance of educating patients.
2024-01-2418 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 79 - Apps, refugees, and the future of digital healthcare“This is only the beginning of making use of this technology.” Professor Marcus Maurer is joined by asthma and allergic rhinitis expert Professor Jean Bousquet to discuss the collaboration that produced the MASK-Air and CRUSE apps, how they are helping Ukrainian refugees and the possibilities for future development.
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Utilise the following external links and access additional resources relating to the topics discussed in this episode: Digitally enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air® approach; M...
2024-01-1116 minUnlocking Myasthenia gravisEpisode 6 – Autoantibodies as biomarkers“Changes in antibody concentrations should influence your therapeutic decision.” Professor Nils Erik Gilhus is joined by Professor Marc De Baets to discuss the importance of regularly measuring autoantibodies to support treatment decisions in people with MG.
2024-01-0514 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 78 - What is cold urticaria?“Wouldn’t it be nice to find a cure?” Professor Marcus Maurer is joined by Dr Aurélie Du-Thanh to discuss cold urticaria, covering risk factors, diagnosis journey, and the most suitable treatment options.
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Utilise the following external links and access additional resources relating to the topics discussed in this episode: Urticaria Group of the French Society of Dermatology, Vibratory urticaria associated with a missense variant in ADGRE2 and Risk factors for systemic reactions in typical cold urticaria: Results from the...
2023-12-2923 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 76 - Clinical nurse specialists: Leading collaborative careProfessor Marcus Maurer is joined by Clinical Nurse Specialist Lorena Lorenzo to discuss the responsibilities of the nurse’s role, and the potential benefits it brings for people living with urticaria.
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Utilise the following external links to access additional resources relating to the topics discussed in this episode: Immunology nursing competency framework and a sponsored article: When is swelling not an allergy?
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2023-12-0419 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 75 - Urticaria in a veterinary settingIn response to listener requests, Professor Marcus Maurer is joined by veterinary specialist Professor Ralf Mueller to discuss how urticaria affects animals, including similarities and differences with the condition in humans and the challenges of treating performance animals.
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Utilise the following external links to access additional resources relating to the topics discussed in this episode: Triggers, risk factors and clinico-pathological features of urticaria in dogs – a prospective observational study of 24 cases and Equine allergic skin diseases: Clinical consensus guidelines of...
2023-11-1716 minUnlocking Myasthenia gravisEpisode 5 – Myasthenia gravis: A global perspectiveProfessor Nils Erik Gilhus welcomes South African neurologist Professor Jeannine Heckmann to discuss variability in MG presentation and treatment, and the impact of infections such as HIV between countries.
2023-11-1719 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 74 - Non-steroidal anti-inflammatory drugs in CSUProfessor Riccardo Asero joins Professor Marcus Maurer to offer advice on the use of non-steroidal anti-inflammatory drugs (NSAID) in people with chronic spontaneous urticaria (CSU). The experts discuss risk assessment and strategies to avoid respiratory and cutaneous hypersensitivity reactions in people who require these common medications to manage comorbidities.
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Utilise the following external links to access additional resources relating to the topics discussed in this episode: Nonsteroidal anti-inflammatory drugs hypersensitivity in chronic spontaneous urticaria in the light of its...
2023-11-0623 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 73 - Urticaria and stressProfessor Marcus Maurer is joined by Professor Eduardo Souza Lima to explore the relationship between stress and urticaria, and the implications of mast cells and neuropeptides in chronic spontaneous urticaria.
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Utilise the following external links to access additional resources relating to the topics discussed in this episode: Neuro-Immuno-Psychological Aspects of Chronic Urticaria, Expression of Hypothalamic-Pituitary-Adrenal Axis in Common Skin Diseases: Evidence of its Association with Stress-related Disease Activity, Psychological Stress and Chronic Urticaria: A Neuro-immuno-cutaneous Crosstalk. A Systematic Review...
2023-10-2322 minUnlocking Myasthenia gravisEpisode 4 – Targeted therapies in myasthenia gravisDr Jennifer Spillane joins Professor Nils Erik Gilhus to discuss how recently launched medications targeting the pathogenic mechanisms of MG will impact management of the condition and the lives of patients.
2023-10-2018 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 72 - IL-9, IL-10 and CSU pathogenesisDermatologist Professor Kiran Godse joins Professor Marcus Maurer to explore the use of JAK and STAT inhibitors in the management of chronic urticaria and how these drugs may impact quality of life for people with this condition.
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Utilise the following external links to access additional resources relating to the topics discussed in this episode: Role of IL-9 and IL-10 in the pathogenesis of chronic spontaneous urticaria through the JAK/STAT signalling pathway and Efficacy of Oral Ruxolitinib in a...
2023-10-0618 minUnlocking Myasthenia gravisEpisode 3 – Myasthenia gravis: A patient perspectiveDr Maria Teresa Ferretti hosts this special podcast edition in which she is joined by Maya Uccheddu, a pharmacist who lives with MG, to hear about the patient experience from diagnosis to treatment and to discuss the patient–doctor relationship.
2023-09-1514 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 70 - Urticaria management in resource-poor settingsDr Désirée Larenas-Linnemann and Professor Marcus Maurer delve into best practices for urticaria management in resource-poor settings, underlining the crucial role of accurate diagnosis and adherence to established guidelines. They also address trending topics in angioedema and urticaria treatment, such as antihistamine up-dosing and the complexities surrounding triple-combination therapies and the need for better education.
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Utilise the following external links to access additional resources relating to the topics discussed in this episode: Mexican Guide to the Diagnosis an...
2023-09-1420 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 69 - The burdens of angioedemaProfessor Marcus Maurer is joined by Professor Paula Busse to explore the multifaceted burdens of angioedema for patients and physicians. They discuss issues surrounding timely diagnosis, interpreting ambiguous symptoms, patient concerns about medications, and enhancing quality of life monitoring.
Utilise the following external links to access additional resources relating to the topics discussed in this episode: Assessment of disease activity and quality of life in patients with recurrent bradykinin-mediated versus mast cell-mediated angioedema, The international WAO/EAACI guideline for the management of hereditary angioedema – The 2021 revision and update and the CARE Registry.
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2023-08-2424 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 68 - Angioedema and CSUDr Régis de Albuquerque Campos joins Professor Marcus Maurer to discuss the implications of angioedema and its impact on people living with chronic spontaneous urticaria (CSU). Dr Campos highlights diverse aspects of the burden of CSU and the impact misdiagnosis has on quality of life. Professor Maurer provides an overview of the current treatment landscape, differential diagnosis, unmet needs in angioedema clinical trials and the utilisation of omalizumab in managing angioedema associated with CSU.
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Utilise the following external l...
2023-08-1123 minUnlocking Myasthenia gravisEpisode 2 – EAN 2023: Highlights and key takeawaysProfessor Francesco Saccà joins Professor Nils Erik Gilhus to review sessions and research presentations focusing on MG from the European Academy of Neurology 2023 Congress, and to reflect on the congress’s key discussion points.
2023-07-2722 minUnlocking Myasthenia gravisEpisode 1 – Myasthenia gravis 101: Disease burden, diagnosis, treatment landscape, and outcomesProfessor Nils Erik Gilhus and Professor Jan De Bleecker discuss the impact of early diagnosis on patient outcomes and provide expert-led insight into the treatment options available to patients with MG based on the latest research.
2023-07-2719 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 67 - Angioedema and artificial intelligenceProfessor Markus Magerl joins Professor Marcus Maurer in this episode to explore the significance of differential diagnosis in the identification of angioedema in chronic spontaneous urticaria (CSU). Professor Magerl takes a deep dive into the prospective use of artificial intelligence (AI) in the analysis of data derived from a questionnaire utilising algorithmic models. Both professors, Maurer and Magerl, discuss the implications AI can have in enhancing the diagnostic accuracy of angioedema.
Utilise the following external links to access additional resources relating to the topics discussed in this episode: 10 Questions - Using AI for diagnosing your or your patient´s angioedema, D...
2023-07-2721 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 66 - Urticaria and the CRUSE appProfessor Marcus Maurer is joined by Dr Aistė Ramanauskaitė to explore the CRUSE app's potential advantages for individuals suffering from chronic spontaneous urticaria. Professor Maurer emphasises the importance and utilisation of the CRUSE app, while Dr. Ramanauskaitė delves into the various benefits and practical applications offered by the app.
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Utilise the following external link to access additional resources relating to the topics discussed in this episode: UCARE YouTube Channel.
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2023-07-1726 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 65 - Audience proposed question: Guidance for potential treatments of CSUProfessor Martin Metz joins Professor Marcus Maurer to answer an audience proposed question focusing on what will guide physicians in the recommendations for individual patients to identify the most beneficial treatment option to treat chronic spontaneous and inducible urticaria. Both experts delve into the current treatment options available, and exciting treatments that are currently in clinical trials.
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Utilise the following external links to access additional resources relating to the topics discussed in this episode: Dupilumab in CSU, Remibrutinib in...
2023-07-0325 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 64 - Urticaria: A general practitioner’s perspectiveProfessor Marcus Maurer is joined by GP Dr Dermot Ryan to discuss the role of GPs in the diagnosis and management of chronic urticaria. Professor Maurer and Dr Ryan highlight the positive impact that physicians have in limiting patient distress while increasing patient confidence, despite the time-limited interactions. They also explore the impact of mistreatment on a patient’s life.
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The international EA...
2023-06-2328 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 61 - Bruton’s tyrosine kinase inhibitors in the treatment of CSUProfessor Karla Arruda and Professor Marcus Maurer discuss the development and implementation of UCARE in Brazil, and its potential benefits for individuals suffering from chronic spontaneous urticaria (CSU). The conversation extends towards exploring the framework of the Brazilian UCARE centres and projects, and how it can be implemented in other countries. Professor Maurer delves into the clinical efficacy, advantages, and impact on patient quality of life of utilising Bruton’s tyrosine kinase inhibitors for the treatment of CSU, along with further discussion of alternative treatments.
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2023-05-0525 minThrombosis in conversationEpisode 6: Treatments and guideline recommendations for managing CATDr Rajasekhar and Dr Barnes consider treatment selection for CAT, highlighting the role of warfarin, and discuss optimal treatment length and the use of IVC filters according to current guidelines.
2023-05-0415 minThrombosis in conversationEpisode 5: Assessment and guideline recommendations for recurrent VTE in patients without cancer“Why did a patient get their blood clot in the first place, and how does that influence our decisions?” Dr Barnes is joined by Dr Anita Rajasekhar for a discussion of the causes and risk factors of VTE in people without cancer, and the relationship of risk and cause with treatment selection. With reference to clinical guidance, Dr Rajasekhar talks about diagnosis of recurrent VTE in the clinical setting and the importance of patient preference.
2023-05-0416 minAll Things Urticaria – Learning about urticaria with Prof. Dr. Torsten ZuberbierEpisode 60 - Updates from AAAAI Conference 2023Professors Marcus Maurer and Luis Felipe Ensina deliberate on the most recent findings that emerged at The American Academy of Allergy, Asthma & Immunology (AAAAI) conference held in San Antonio, Texas. In particular, Professor Maurer discusses poster presentations concerning the efficacious use of omalizumab and dupilumab for the management of urticaria. Professor Ensina expands the discussion by outlining ongoing projects and upcoming projects within UCARE that will be presented at the forthcoming UCARE conference in São Paulo in 2023.
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2023-04-2521 minThrombosis in conversationEpisode 4: Management of challenging CAT and anticoagulationDr Deborah Siegal and Dr Barnes discuss thrombocytopenia and its treatment, including anticoagulation therapy and the inferior vena cava (IVC) filter, and touch on the challenge of balancing bleeding risk with VTE recurrence in people with brain tumours.
2023-04-1319 minThrombosis in conversationEpisode 3: Real-world evidence for VTE“How do we apply [clinical trial data] to patients we see every day in clinic?” Dr Gregory Piazza and Dr Barnes analyse real-world VTE data, highlighting shared decision-making for determining the most suitable anticoagulation therapy for a person with VTE.
2023-04-1316 minThrombosis in conversationEpisode 2: The treatment landscape for CAT“If there is a compliance and an adherence issue, it’s with the injectables” Dr Alok Khorana joins Dr Barnes to discuss the real-world versus clinical trial evidence of adherence to injectables, including the importance of taking a patient’s values and preferences into account when making treatment decisions.
2023-04-1320 minThrombosis in conversationEpisode 1: Identifying and stratifying risk of CATDr Alok Khorana and Dr Barnes examine why cancer can drive higher risk of VTE and the importance of warning patients about the symptoms of a blood clot.
2023-04-1320 min