Shows
CARTA - Anthropogeny (Video)CARTA: Three Smokes in the Evolution of the Human Exposome with Caleb FinchHumans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly ev...2025-07-0317 min
UC San Diego (Video)CARTA: Three Smokes in the Evolution of the Human Exposome with Caleb FinchHumans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly ev...2025-07-0317 min
University of California Video Podcasts (Video)CARTA: Three Smokes in the Evolution of the Human Exposome with Caleb FinchHumans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly ev...2025-07-0317 min
Humanities (Audio)CARTA: Three Smokes in the Evolution of the Human Exposome with Caleb FinchHumans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly ev...2025-07-0317 minHumanities (Video)CARTA: Three Smokes in the Evolution of the Human Exposome with Caleb FinchHumans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly ev...2025-07-0317 min
University of California Audio Podcasts (Audio)CARTA: Three Smokes in the Evolution of the Human Exposome with Caleb FinchHumans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly ev...2025-07-0317 minUC San Diego (Audio)CARTA: Three Smokes in the Evolution of the Human Exposome with Caleb FinchHumans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly ev...2025-07-0317 min
Science (Audio)CARTA: Three Smokes in the Evolution of the Human Exposome with Caleb FinchHumans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly ev...2025-07-0317 minCARTA - Anthropogeny (Audio)CARTA: Three Smokes in the Evolution of the Human Exposome with Caleb FinchHumans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly ev...2025-07-0317 minScience (Video)CARTA: Three Smokes in the Evolution of the Human Exposome with Caleb FinchHumans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly ev...2025-07-0317 minScience (Audio)CARTA: Three Smokes in the Evolution of the Human Exposome with Caleb FinchHumans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly ev...2025-07-0317 min
the carnivore experienceDEBUNKING Robert Cywes Carnivore Lies + More From Our Live Q&AJoin Stephen and Richard for a fired-up live Q&A session where they expose the ridiculous claims made by Robert Siwis about carnivore diets and answer your burning health questions.(As we touch on the ridiculous claims made by Robert Cywes about carnivore diets and blood work I have written up the references and reasons. To see the science behind the debunk please visit the article here https://open.substack.com/pub/theukcarnivore/p/lets-spill-the-tea-and-maybe-the?utm_source=app-post-stats-page&r=14wb5g&utm_medium=ios)🔥 What We Cover: • Why Robert Cywes' 24-minute ChatGPT rant about...2025-06-101h 01
Carnivore Coaches Corner095: Genetics and Epigenetics in Natural BodybuildingTIME STAMPS:02:25 **VIDEO PRESENTATION** - all about GENETICS and EPIGENETICS in natural bodybuilding, and what’s within your control to change long term nutritionally.10:10 mRNA & Ribosomes, and amino acids - definitions of key terms for building muscle.17:20 BROCCOLI: superHERO or superVILLAIN?!27:02 A discussion around how quickly plants should be eliminated when going carnivore and which ones might be wise to keep in temporarily depending on your dieting history.29:09 The misunderstood truth about IRON!!! (Spoiler - you can’t use the iron that’s in spinach) Heme iron & non-heme iron.37:38 IMMUNITY HEALTH & VITAMIN C.56:02 The difference between ANTIOXIDANTS and PRO-OXIDANTS.59:58 CLASTO...2025-02-281h 35
The Dr. Abs PodcastHomeless & Depressed to Carnivore Bodybuilder Champ of Europe | Dr.Abs Podcast #1Richard Smith went from a grown man that looked like a little boy to depressed with anxiety and homeless to a carnivore european bodybuilding champion. His diet allowed him to overcome diabetes, arthritis, anxiety, obesity and more and achieve what he now has. Check out his story. Timestamps below:
-Richard’s life and history-
1:46 Intro
7:07 Health issues on a standard western diet
10:55 Doubling bodyweight and 56% body fat
15:00 Diabetes diagnosis
17:30 Rejecting medication
19:00 Anxiety-ridden
10:00 Bodybuilding motivation seed
20:53 Homeless
22:30 Starting Keto and losing 2 st
24:52 Carb restriction and 12 month transformation
26:01 Start of Bodybuilding
27:19 Hacking insulin for fat burning/storage
29:48 Entering bodybuilding with anxiety
36:33 Eu...2024-08-252h 58
Brianna ApprovedEpisode 67 - Berberine, Not Nature’s Ozempic, But an Amazing Plant Compound & GLP-1 BasicsIn this episode I discuss all things Berberine and why I love it as a plant compound! I discuss Berberine's MOA, benefits, GLP1 basiscs/ how that relates to Ozempic, cellular, and molecular targets for Berberine (such as AMPK + Sirtuins) how it works on dosage and contraindications.
-Berberine Mechanism of Action
-GLP-1 Overview
-Molecular Targets for Berberine (AMPK + Sirtuins +NFKB)
-Dosage & Contraindications
Watch the YouTube Video here
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Be sure to follow my Instagram @briannadiorio for all the Brianna Approved educational content!
You can visit my website www.briannadiorio.com to learn more.
Production Manager and Graphics @kylediorio
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Befriending Anxiety E-Course
My Befri...2024-05-2727 min
Small Stocks, Big MoneyBiovie (NASDAQ: BIVI): Innovating Potential Alzheimer’s and Parkinson’s TreatmentBioVie Inc. (NASDAQ: BIVI) is a clinical-stage company developing innovative drug therapies for the treatment of neurological and neurodegenerative disorders and advanced liver disease. In neurodegenerative disease, the Company’s drug candidate NE3107 inhibits inflammatory activation of ERK and NFkB (e.g., TNF signaling) that leads to neuroinflammation and insulin resistance, but not their homeostatic functions (e.g., insulin signaling and neuron growth and survival). Both are drivers of Alzheimer’s and Parkinson’s diseases. The Company is conducting a potentially pivotal Phase 3 randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate NE3107 in patients who have mild to moderate Alzhei...2023-07-3107 min
Impremix. Letto per voi.NFkB romanzo scientifico - di Renzo Suriani - L'oculistaQuesto libro è una terapia farmacologica sviluppata per migliorare o ridurre i sintomi della depressione del paziente nel rapporto con il medico.
Si legge questo nel “bugiardino” che accompagna il Romanzo scientifico di Renzo Suriani, medico a sua volta e autore di questo libro, spassoso, sarcastico, ironico e severo, che dà una pennellata di verità al mondo della sanità, e della salute2023-01-0404 min
Antibuddies6 shades of NFkB #2We continue our discussion with Dr. Adewunmi Adelaja (M.D., Ph.D.), from the University of California Los Angeles, about NFkB signaling and how signals to different stimuli are relayed inside macrophages.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Article of discussion: Six distinct NFκB sign...2022-02-2752 minAntibuddies6 shades of NFkB #1We sit down with Dr. Adewunmi Adelaja (M.D., Ph.D.) from the University of California Los Angeles to discuss NFkB signaling and how signals to different stimuli are relayed inside macrophages.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Article of discussion: Six distinct NFκB sign...2022-02-1849 min
Inflammation Nation: Science Informed Wellness019 Weight Loss and Inflammation Part 7 - Herbs that control NfKB to not be inflamedSend us a textAll inflammatory triggers have one thing in common...they are trying to activate something called NFkB. Luckily, nature gives us several natural compounds that have been extensively researched for their ability to shut down NFkB and reduce inflammation. Hit the subscribe or follow button to be notified when new episodes drop. Rate and review your favorite episodes to let me know the things you like so I can keep delivering great content that brings value to your life and health.You can listen to the Inflammation Nation podcast on 2022-01-2311 min
The Autoimmune Doc Podcast w/ Dr. Taylor Krick027 - Mold, Mycotoxins and AutoimmunityYoutube Video: Mold Toxicity and Mycotoxin IllnessYoutube Video: Research Review - Neural Antibodies in Patients with Symptoms and Histories of Mold/Chemical ExposuresYoutube Video: Research Review - Mycotoxins Induce NeurotoxicityI say this all the time, but mold toxicity is crazy. Indoor molds such as Aspergillus, Penicillium, and Stachybotrys produce mycotoxins, which are also crazy. Mold and mycotoxins can both disrupt the immune system in a myriad of different ways, which is why they are associated with autoimmunity in many ways.In this podcast, I didn't want...2021-11-1634 min
The Autoimmune Doc Podcast w/ Dr. Taylor Krick008 - Which Supplements Work Best for Autoimmunity?View the products I mention at: www.AutoimmuneEducationAcademy.com There are TONS of supplements out there today, and they all have promising claims, but in my functional medicine practice I see people all the time who have been let down by supplements. Many of them bring bags of products in, and often they weren’t a bad idea, it might even be some things that I like to use often, but they are still not feeling well because they haven't figured out the right dosage or combination for THEM. Then, when they begin to understand the mechanisms of...2021-04-2028 min
Jogging Bonito#15 Micheline aime courir et vous em...brasse !OMAGAD ! Vous allez écouter le nouvel épisode de Jogging Bonito (le 15e !) avec une invitée exceptionnelle, en la personne de MICHELINE (copyright nfkb ici même si on connait tous une Micheline à la machine à café). Non en fait on déconne, Micheline, elle n'a pas envie de parler, elle s'en fout des paillettes, du show-business des podcasts, elle fait son truc et c'est très bien.
Dans cet épisode néanmoins, vous entendrez parler d'elle car Emir reviendra sur les barrières (dans la gueule) horaires au marathon de Paris après que David vous aura convaincu de...2018-05-111h 22
Velotaf de nfkbBlack MirrorBlack Mirror by nfkb2018-01-2700 minJogging Bonito#8 - e-commerce, GRP, UTMB, Marjy Superstar et QUIZ (YouTube Live)En août, nous vous avons retrouvés pour un Live sur YouTube.Une première pour nous !Nous tenons à vous dire que nous avons passé une excellente soirée en votre compagnie, même si on a bien compris que vous veniez pour nous voler la vedette.Voici donc la version audio de cette émission spéciale dépouillé du moment où Emir a fait la liste complète de tous les puristes qu'il voulait insulter, ou de celui au cours duquel David a enjoint l'assistance à prier pour Sainte Anne Dubndidu (et d'autres moments pas très écoutable...2017-09-182h 00
Velotaf de nfkbHasard et habitudesHasard et habitudes by nfkb2017-08-0209 minJogging Bonito#6.5 - Tétons ensanglantés : le mystère enfin résolu ?Coucou !
Cet épisode est la suite de l'épisode 6.Il s'agit des questions posées par vous, les auditeurs. On aura votre peau.
Au menu, en vrac :
Karine Le Marchand
Rémi nfkb
Préparation à la première fois
Souvenirs de la détermination/de la douleur
surpoids
kilométrage
Lesly l'ostéo
SaintéLyon
Mamelons
Couple
Coups de bâtons
Sub2h au Marathon
Joey et Justin
Anniversaire
d'autres trucs
Mettez-nous en avant sur iTunes en nous laissant une note et/ou un commentaire ici : itunes.apple.com/fr/podcast/joggi…d1165951201?mt...2017-06-1958 min
Velotaf de nfkbLa boucle est boucléeUne histoire de SAV et de transport.2017-03-2111 minJogging Bonito#4 - 50 nuances de gels énergétiquesSalut les Bonitos !
Au sommaire de cet épisode du mois de février 2017 :
L’industrie du dossard
L’esprit trail, faut-il y croire ?
L'estomac du coureur du fond
Emir nous dira si ses dossards lui servent de tapisserie. Rémi nous expliquera les trucs qu'on peut faire avec des antioxydants. David se fera des amis barbus et Marjy fera ce qu'elle peut pour mater tout ce petit monde. Approximativement.
Nous avons pris notre temps pour publier ce numéro de février mais notez que nous sommes encore dans les délais. La barrière h...2017-02-271h 24Jogging Bonito#3 - Restez motivés, nous ne sommes qu'en janvierChers Bonitos,
Voici les thèmes de ce 3e épisode de JOGGING BONITO, votre podcast de course à pied (janvier 2017, l'épisode de la coruscation):
Non à la PPG !
Les 7 astuces cachées que les vrais coureurs n'ignorent pas en 2017
Instagram m'a motivER
Dans cet épisode, Marjy, notre intelligence artificielle, nous propose un défi.Rémi, lui, vous donne ses astuces pour repeindre vos murs tout en effectuant des exercices à la presse à cuisses.Emir veut devenir chroniqueur chez LePape-Info.Et enfin David va casser l'ambiance et encore se faire des ennemis.
Offrez-nous...2017-01-151h 10Jogging Bonito#2 - Confessions d'un slow runner junkieBonitas, Bonitos,
Voici les thèmes de ce 2e épisode de JOGGING BONITO (décembre 2016, l'épisode de la maturité):
J’ai testé le slow running
TSSspotting, une histoire de dopamine junkie
Confessions d’un testeur de produits
Grosses surprises pour cet épisode.Nous rendons tout d'abord un hommage à notre Papa-Podcast @rivieradetente qui nous a recommandé la cousine sportive de Marie XB4002. Eh oui, il y a du nouveau dans l'équipe...
Nous disposons enfin de notre Instagrameuse, Émile nous a quitté pour la concurrence et nous avons été obligés de prendre un compte p...2016-12-121h 02Jogging BonitoJogging Bonito #1 - Un podcast par mois, pas plus !Chères Bonitas, chers Bonitos,
Au programme de cet épisode 1 de JOGGING BONITO (novembre 2016, l'épisode de la confirmation) :
2 marathons par an, pas plus !
The Sound of Silence
Le blogging et moi
N'hésitez pas à prendre 2 RTT pour écouter les réactions (intéressantes) de Rémi. Tapez 1 si vous pensez que David est insupportable. Tapez sur Emir si vous pensez qu'il est irresponsable. Ou tapez vous Emile si vous avez la dalle.
Merci d'avoir accordé tant d'amour à notre épisode pilote. Vous avez toute notre sympathie, même si vous exposez vos vieux dossards de c...2016-11-151h 07Jogging BonitoJogging Bonito #0 - Le piloteChères Bonitas, chers Bonitos,
Au programme de cet épisode 0 de JOGGING BONITO (octobre 2016) :
Data WaterBoardingLes données recueillies pendant le sport : amies ou ennemies ?
Coaché par Anne Dubndidu1000 et 1 façons de retrouver la motivation. La 992e, c’est Anne Dubndidu et vous n’allez pas être déçus.
Le marketing, ami ou ennemi du Runner ?Une chronique sponsorisée par Nike, adidas, Salomon, Hoka, Puma, Asics, Mizuno, Garmin, TomTom, Altra, Brooks, Raidlight, NB et les monte-escaliers Stannah.
N'hésitez pas à nous faire savoir si vous connais...2016-10-1358 min
Velotaf de nfkbVelotaf #8Cerveau ralenti par le lendemain de garde, je marmonne des trucs2016-04-2117 min
Velotaf de nfkbVélotaf #7Où je refais le match après avoir écouté Studio 404 de février puis je disserte sur vitamine C et hypoglycémie et autres choses.2016-03-0518 min
Velotaf de nfkbVelotaf #6En réponse à l'épisode de Réadio sur la lucation de rotule aux urgences. https://soundcloud.com/subutox/il-est-bizarre-son-genou-nan2016-02-0619 min
Velotaf de nfkbVelotaf #5Un vélotaf sur la nécessaire circulation entre les habitudes et l'innovation.2016-01-1619 min
Velotaf de nfkbVelotaf #4 : mon parcoursLe parcours de nfkb dans les méandres des études de médecine.2016-01-0823 min
Velotaf de nfkbVélotaf #3Un petit vélotaf sur la nutrition, les régimes et les compléments alimentaires2016-01-0420 min
Velotaf de nfkbVeloparlé #2(admirez le tape dégueulasse pour attacher une sacoche moche sur une selle Brooks, les Velominati m'enverraient brûler en enfer s'ils voyaient ça)2016-01-0214 min
Velotaf de nfkbVelotaf #1bike n' talk sur l'hypnose conversationnelle2015-12-2920 min
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 04/07Beeinflusst die perioperative Gabe von Moxifloxazin die zerebrale inflammatorische Reaktion und das neurokognitive Outcome 14 Tage nach extrakorporaler Zirkulation mit tief- hypothermem Kreislaufstillstand bei der Ratte ?Die hier vorliegende Studie soll den Einfluss der perioperativen Gabe von Moxifloxazin (MXF) auf das neurokognitive Outcome und den histologischen Schaden 14 Tage nach extrakorporaler Zirkulation (EKZ) mit 45 min tief- hypothermem Kreislaufstillstand (DHCA) bei der Ratte untersuchen. 50 männliche Sprague- Dawley Ratten (330-400 g) wurden randomisiert drei Gruppen zugeteilt: Kontrolle (n=10), Sham und DHCA (je n=20). Die Sham- und DHCA- Tiere wurden weiter unterteilt in MXF und Plazebo behandelte Gruppen (n=10). Die Tiere erhielten intraperitoneal mit Beginn der Anästhesie alle zwei Stunden 6 x 100 mg/kg MXF bzw. dasselbe Volumen physiologische Kochsalzlösung. Tiere der DHCA- Gruppen wurden intubiert, mit Isofluran (2,0-2...2010-02-1300 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 11/19Die Rolle der Wechselwirkung von p53 und NFkB für den sekundären Hirnschaden nach Schädel-Hirn TraumaIn der Pathophysiologie des Schädel-Hirn Traumas unterscheidet man Primär- und Sekundärschaden. Der Primärschaden kommt durch die initiale Gewalteinwirkung zustande und kann therapeutisch nicht beeinflusst werden. Der Sekundärschaden setzt nach einer gewissen Zeit (Stunden bis Tage) ein, und führt zur Progression von Verletzung und neurologischer Dysfunktion. Apoptotischer Zelluntergang von Neuronen kann im Kortex von Patienten nach Schädel-Hirn Trauma nachgewiesen werden und stellt möglicherweise eine Ursache für die sekundäre klinische Verschlechterung dar. In der Regulation der neuronalen Apoptose besitzt p53 und NFкB eine Schlüsselfunktion. P53 kann als übergeordnetes Steuermolekül den Zellunterg...2010-01-2100 min
Medizin - Open Access LMU - Teil 15/22A novel technique for selective NF-kappa B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion.Background and aims: The transcription factor nuclear
factor kappa B (NF-kB) has risen as a promising target for
anti-inflammatory therapeutics. In the liver, however, NFkB
inhibition mediates both damaging and protective
effects. The outcome is deemed to depend on the liver
cell type addressed. Recent gene knock-out studies
focused on the role of NF-kB in hepatocytes, whereas the
role of NF-kB in Kupffer cells has not yet been
investigated in vivo. Here we present a novel approach,
which may be suitable for clinical application, to
selectively target NF-kB in Kupffer cells and analyse the
effects in experimental models of liver...2009-01-0100 minFakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 02/06Biochemical and cell biological characterisation of Sumo E1 activating enzyme Aos1/Uba2Small ubiquitin-related modifier (SUMO) is a protein that is attached to lysine residues in a variety of target proteins. Sumoylation of proteins can alter their intracellular localisation, stability, activity and interaction with other proteins. The pathway of sumoylation is analogous to that of ubiquitination. The reaction is ATP dependent and requires the E1-activating enzyme (Aos1/Uba2), the E2-conjugation enzyme (Ubc9) and for most target proteins SUMO E3 ligases.
The aim of this study was to characterise the SUMO E1 enzyme, a heterodimer consisting of the subunits Aos1 and Uba2. On one hand I characterised an Uba2 splice variant...2005-12-2000 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 04/19Die Bedeutung von akuter und subakuter endothelialer Aktivierung für den myokardialen ReperfusionsschadenDie Arbeit untersucht die Bedeutung der Blockade von NFkB in der akuten und subakuten myokardialen Reperfusion im Vergleich zur Blockade von CD18. Wir führten die Versuche an deutschen Landschweinen in vivo durch mit einer Reperfusionsdauer von 24h bzw 7d. Durch die lange Dauer der Reperfusion konnten die Prozesse der subakuten Phase der Reperfusion ablaufen, sodass wir die Bedeutung der akuten und der subakuten Phase gegeneinander abwiegen konnten. Sowohl die Blockade von CD18 als auch die Blockade von NFkB konnten bezüglich der Parameter Leukozyteninfiltration, Infarktgröße und Myokardfunktion benefizielle Effekte erzielen, in der Kombination zeigten sich additive Effekte. Die Bloc...2005-10-2000 minFakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 01/06Identifizierung und Charakterisierung von Zielgenen des Epstein-Barr Virus nukleären Antigens 2 (EBNA2)Das Epstein Barr Virus (EBV) ist ein ubiquitär vorkommendes Herpesvirus, mit dem etwa weltweit 90% der erwachsenen Bevölkerung permanent infiziert sind. Die zumeist asymptomatisch verlaufende Infektion betrifft primäre B–Zellen des Rachenraumes, die nach Aufnahme des Virus entweder zur Virus-Produktion (lytischer Zyklus) oder zur Proliferation angeregt werden (Latenzprogramm, Entstehung von B-Lymphoblasten). Letzteres wird durch den viralen Transkriptionsfaktor EBNA2 kontrolliert, der durch seine viralen und zellulären Zielgene ruhende B-Zellen in vitro immortalisieren kann. Die EBV-infizierten B-Lymphoblasten werden in vivo effizient durch T-Zellen erkannt und abgetötet. EBV entkommt der Immunantwort durch Persistenz in Gedächtnis-B-Zellen, die vermutlich durch Differen...2003-10-3000 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 01/19Charakterisierung von HSS-2, einer B-zellspezifischen, regulatorischen DNA-Sequenz im Bereich des Ig(lambda)-Enhancers des MenschenDer menschliche Igl-Enhancer besteht aus den drei DNase I-hypersensitiven Regionen HSS-1, -2 und -3, wobei HSS-3 den eigentlichen Enhancer darstellt und HSS-1 und -2 gemeinsam auf HSS-3 synergistisch wirken.
Ziel der vorliegenden Arbeit war es, die B-zellspezifische Region HSS-2 näher einzugrenzen und zu charakterisieren.
Dazu wurden transiente Transfektionen und In-vivo-Footprinting-Versuche durchgeführt.
Die Transfektionsexperimente erfolgten mit den reifen B-Zelllinien MN60 und Daudi. Dazu wurden Luciferasereportergenkonstrukte mit Punktmutationen in den beiden NFkB-Bindungsstellen von HSS-2 oder mit 5’- bzw. 3’-Deletionen in HSS-2 eingesetzt. Die Auswertung der Daten ergab, daß der Transkriptionsfaktor NFkB eine sehr wichtige Rolle in der Regulierung des humanen Igl-Loc...2002-12-1800 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 01/19Charakterisierung von HSS-2, einer B-zellspezifischen, regulatorischen DNA-Sequenz im Bereich des Ig(lambda)-Enhancers des MenschenDer menschliche Igl-Enhancer besteht aus den drei DNase I-hypersensitiven Regionen HSS-1, -2 und -3, wobei HSS-3 den eigentlichen Enhancer darstellt und HSS-1 und -2 gemeinsam auf HSS-3 synergistisch wirken.
Ziel der vorliegenden Arbeit war es, die B-zellspezifische Region HSS-2 näher einzugrenzen und zu charakterisieren.
Dazu wurden transiente Transfektionen und In-vivo-Footprinting-Versuche durchgeführt.
Die Transfektionsexperimente erfolgten mit den reifen B-Zelllinien MN60 und Daudi. Dazu wurden Luciferasereportergenkonstrukte mit Punktmutationen in den beiden NFkB-Bindungsstellen von HSS-2 oder mit 5’- bzw. 3’-Deletionen in HSS-2 eingesetzt. Die Auswertung der Daten ergab, daß der Transkriptionsfaktor NFkB eine sehr wichtige Rolle in der Regulierung des humanen Igl-Loc...2002-12-1800 min